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Aneuploidy, as a result of numerical changes in chromosome number, was observed in tumours almost a century ago. The molecular mechanisms underlying this phenomenon and their impact on tumour development are still poorly understood. A series of recent observations provide direct linkages between the normal function of tumour suppressor proteins and the suppression of aneuploidy. The prospects t...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2000
ISSN: 1465-542X
DOI: 10.1186/bcr63